E-Journal of Chemistry (Jan 2006)
Synthesis and Antimicrobial Activity of Newer Quinazolinones
Abstract
2–alkyl–6–bromo–3,1–benzoxazine–4–one (2) is synthesized by treating p–Bromoanthranilic acid and Acetylechoride or Benzoylchloride. Reaction of 2–alkyl–6–bromo–3,1–benzoxazine–4–one (2). with hydrazinehydrate furnish the corresponding 3–Amino–2–methyl–6–bromoquinazoline–4(3H)–one (3) which on reaction with benzaldehyde afford N,N – arylidene derivative (4). Reaction of 4 with various diazonium salts yields 6–bromo–2–alkyl/aryl–3{[phenyl(phenyldiazenyl)methylene]amino}quinazolin–4(3H)–one .