E-Journal of Chemistry (Jan 2006)

Synthesis and Antimicrobial Activity of Newer Quinazolinones

  • J. A. Patel,
  • B. D. Mistry,
  • K. R. Desai

DOI
https://doi.org/10.1155/2006/586512
Journal volume & issue
Vol. 3, no. 2
pp. 97 – 102

Abstract

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2–alkyl–6–bromo–3,1–benzoxazine–4–one (2) is synthesized by treating p–Bromoanthranilic acid and Acetylechoride or Benzoylchloride. Reaction of 2–alkyl–6–bromo–3,1–benzoxazine–4–one (2). with hydrazinehydrate furnish the corresponding 3–Amino–2–methyl–6–bromoquinazoline–4(3H)–one (3) which on reaction with benzaldehyde afford N,N – arylidene derivative (4). Reaction of 4 with various diazonium salts yields 6–bromo–2–alkyl/aryl–3{[phenyl(phenyldiazenyl)methylene]amino}quinazolin–4(3H)–one .