Pharmaco-epigenetics: Histone modification and personalized medicine

Abstract

Epigenetic changes have a major effect in both normal and disease cases of organism. Multiple types of epigenetic changes as acetylation, methylation on either DNA or histone proteins, phosphorylation, or ubiquitination. Epigenetic changes are associated with multiple diseases; one of the major diseases that bind with epigenetic changes is cancer. However, DNA methylation is one of the most important epigenetic changes that leads to disease such as cancer. Moreover, patients respond differently to drugs due to different genetic makeup or what called molecular changes in their cells. Both genetic and epigenetic are important to determine the personalized medicine “precise medicine”. This review will discuss the epigenetic changes in our body and how it’s affected personalized medicine for each person.