Nature Communications (Feb 2021)

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

  • Seiya Ozono,
  • Yanzhao Zhang,
  • Hirotaka Ode,
  • Kaori Sano,
  • Toong Seng Tan,
  • Kazuo Imai,
  • Kazuyasu Miyoshi,
  • Satoshi Kishigami,
  • Takamasa Ueno,
  • Yasumasa Iwatani,
  • Tadaki Suzuki,
  • Kenzo Tokunaga

DOI
https://doi.org/10.1038/s41467-021-21118-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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SARS-CoV-2 D614G spike protein mutation is one of the predominant circulating vital mutants. Here, Ozono et al. demonstrate that D614G mutation increases in vitro cell entry by acquiring higher affinity to ACE2.