COFUNCTIONING OF PROTECTIVE SYSTEMS: MUCOSAL IMMUNITY AND HUMAN COMPLEMENT SYSTEM

Abstract

Results on cofunctioning innate mucosal immunity (MI) and human complement system (HCS) pathways at steps of HCS initiation, amplification and termination were summarized. Receptor participants and pattern recognizing molecules (oligomeric lectins, multifunctional-site mucins and glycoproteins) of HCS and MI are taking into consideration. The ways of antipathogen cofunctioning MI and HCS are shown. The cases of viral, bacterial and fungal pathogens which use components, agent ingredients and reactions of HCS and Ml in pathogen strategies of invasion and survival in organism are represented. Prospects of cofunctioning MI and HCS, strategic directions of MI and HCS combinative using in development of medical aspects, constructing drugs and compositions of medical biotechnology significance are suggested and argued.

Keywords

• mucosal immunity
• complement system
• mucins
• lectins
• pathogens
• viruses
• bacteria
• fungi