Recent Advances in Understanding Neutrophil Extracellular Traps inthe Context of Gastrointestinal Cancer

Abstract

Neutrophil extracellular traps(NETs) constitute fibrous structures released by neutrophils,with the formation process termed NETosis.Emerging research has unveiled the multifaceted role of NETs in promoting the genesis and development of cancer through diverse mechanisms.Significantly,their close association with the progression and metastasis of various malignant cancers has been established.Meanwhile,the escalating morbidity and mortality rates of gastrointestinal cancers in China underscore the pressing need for a comprehensive understanding of NETs in the context of digestive tract malignancies.This paper systematically reviews the intricate process of NET formation and its pivotal role in the landscape of digestive tract cancers.

Keywords

• neutrophil extracellular traps
• netosis
• gastrointestinal cancer