Angiogenesis stimulation in bacteria-infected acute wound healing with honey treatment in BALB/C mice

Abstract

The use of honey for wound healing has been carried out several times, but until now no one has compared the effectiveness of honey from various types of honey found in Indonesia for stimulating the formation of new blood vessels (Angiogenesis) in acute wounds infected with bacteria. The other side of wound healing that will be observed in this study is that wounds are often exacerbated by conditions of infection due to bacteria. The purpose of this study was to determine the level of stimulation of wound healing by treating honey in acute wounds infected with bacteria. This study was divided into 4 groups, namely the control group (K-MD), the first treatment group with Javanese Honey (MD-JW), the second treatment group with Kalimantan Forest Honey (MD-KLM) and the third treatment group with NTT Honey. (MD-NTT). In the results of the study, the highest VEGF levels were found in the MD-NTT group, followed by the MD-JW group, then the MD-KLM group and the lowest were in the K-MD group. The OneWay Anova test obtained p>0.05 and the Post Hoc LSD test showed that the average VEGF levels in the MD-NTT, MD-JW and MD-KLM groups were significantly higher than the K-MD group (p <0.05). In this study, it can be concluded that giving honey from NTT can increase Vascular Endothelial Growth Factor (VEGF) levels better than honey from Java and Kalimantan in healing acute wounds infected with bacteria in BABL/C mice.