Nature Communications (Sep 2019)
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
- David P. Labbé,
- Giorgia Zadra,
- Meng Yang,
- Jaime M. Reyes,
- Charles Y. Lin,
- Stefano Cacciatore,
- Ericka M. Ebot,
- Amanda L. Creech,
- Francesca Giunchi,
- Michelangelo Fiorentino,
- Habiba Elfandy,
- Sudeepa Syamala,
- Edward D. Karoly,
- Mohammed Alshalalfa,
- Nicholas Erho,
- Ashley Ross,
- Edward M. Schaeffer,
- Ewan A. Gibb,
- Mandeep Takhar,
- Robert B. Den,
- Jonathan Lehrer,
- R. Jeffrey Karnes,
- Stephen J. Freedland,
- Elai Davicioni,
- Daniel E. Spratt,
- Leigh Ellis,
- Jacob D. Jaffe,
- Anthony V. DʼAmico,
- Philip W. Kantoff,
- James E. Bradner,
- Lorelei A. Mucci,
- Jorge E. Chavarro,
- Massimo Loda,
- Myles Brown
Affiliations
- David P. Labbé
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Giorgia Zadra
- Department of Oncologic Pathology, Dana-Farber Cancer Institute
- Meng Yang
- Department of Nutrition, Harvard T.H. Chan School of Public Health
- Jaime M. Reyes
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Charles Y. Lin
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Stefano Cacciatore
- Cancer Genomics Group, International Centre for Genetic Engineering and Biotechnology
- Ericka M. Ebot
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Amanda L. Creech
- The Broad Institute of MIT and Harvard University
- Francesca Giunchi
- Pathology Service, Addarii Institute of Oncology, S-Orsola-Malpighi Hospital
- Michelangelo Fiorentino
- Pathology Service, Addarii Institute of Oncology, S-Orsola-Malpighi Hospital
- Habiba Elfandy
- Department of Oncologic Pathology, Dana-Farber Cancer Institute
- Sudeepa Syamala
- Department of Oncologic Pathology, Dana-Farber Cancer Institute
- Edward D. Karoly
- Metabolon
- Mohammed Alshalalfa
- Decipher Biosciences
- Nicholas Erho
- Decipher Biosciences
- Ashley Ross
- James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions
- Edward M. Schaeffer
- Northwestern University Feinberg School of Medicine
- Ewan A. Gibb
- Decipher Biosciences
- Mandeep Takhar
- Decipher Biosciences
- Robert B. Den
- Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University
- Jonathan Lehrer
- Decipher Biosciences
- R. Jeffrey Karnes
- Department of Urology, Mayo Clinic Rochester
- Stephen J. Freedland
- Department of Surgery, Division of Urology, Center for Integrated Research on Cancer and Lifestyle, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center
- Elai Davicioni
- Decipher Biosciences
- Daniel E. Spratt
- Department of Radiation Oncology, University of Michigan
- Leigh Ellis
- Department of Oncologic Pathology, Dana-Farber Cancer Institute
- Jacob D. Jaffe
- The Broad Institute of MIT and Harvard University
- Anthony V. DʼAmico
- Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School
- Philip W. Kantoff
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- James E. Bradner
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Lorelei A. Mucci
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Jorge E. Chavarro
- Department of Nutrition, Harvard T.H. Chan School of Public Health
- Massimo Loda
- Department of Oncologic Pathology, Dana-Farber Cancer Institute
- Myles Brown
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-12298-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Prostate cancer progression may be enhanced by a high-fat diet. Here the authors show that a diet high in saturated fats enhance the MYC-driven transcriptional program, a feature that independently predicts prostate cancer progression and death.
