Communications Biology (Nov 2022)
The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition
- Dennis van der Meer,
- Tiril P. Gurholt,
- Ida E. Sønderby,
- Alexey A. Shadrin,
- Guy Hindley,
- Zillur Rahman,
- Ann-Marie G. de Lange,
- Oleksandr Frei,
- Olof D. Leinhard,
- Jennifer Linge,
- Rozalyn Simon,
- Dani Beck,
- Lars T. Westlye,
- Sigrun Halvorsen,
- Anders M. Dale,
- Tom H. Karlsen,
- Tobias Kaufmann,
- Ole A. Andreassen
Affiliations
- Dennis van der Meer
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Tiril P. Gurholt
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Ida E. Sønderby
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Alexey A. Shadrin
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Guy Hindley
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Zillur Rahman
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Ann-Marie G. de Lange
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Oleksandr Frei
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Olof D. Leinhard
- AMRA Medical
- Jennifer Linge
- AMRA Medical
- Rozalyn Simon
- Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences, Linköping University
- Dani Beck
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Lars T. Westlye
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Sigrun Halvorsen
- Department of Cardiology, Oslo University Hospital Ullevål, and University of Oslo
- Anders M. Dale
- Center for Multimodal Imaging and Genetics, University of California at San Diego
- Tom H. Karlsen
- Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet
- Tobias Kaufmann
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Ole A. Andreassen
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- DOI
- https://doi.org/10.1038/s42003-022-04237-4
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 10
Abstract
A GWAS study of European individuals uncovers genetic associations between whole-body MRI derived measures and cardiometabolic diseases and highlights the key role of liver fat in cardiometabolic health.
