A new evaluation of the rearranged non-coding control region of JC virus in patients with colorectal cancer

Abstract

Highlights A significant proportion of 35/60 (58.33%) tumor tissue and 42/60 (70%) urine samples of the CRC patients were found to be positive for JCV DNA (P = 0.25). The parallel analysis of tumor and urine samples for JCV DNA further supports the potential for non-invasive screening tools. screening JCV DNA in peripheral blood mononuclear cells (PBMCs) and stool of CRC patients may further support the potential for non-invasive screening tools. The study offers new insights into rearranged NCCR variants isolated from colorectal cancer (CRC) patients’ tissue. The screening and analysis of the rrNCCR region of JCV DNA in CRC patients’ stool may indicate the pathogenesis of the JCV virus in CRC development. The presence of JCV LTAg in tumor tissue is significantly higher than in normal tissue (p = < 0.002), suggesting JCV’s role in cancer development during the latency phase.

Keywords

• Colorectal neoplasms
• Nested polymerase chain reaction, JC virus
• Genotypes