CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors

Sarah M. Lloyd; Daniel B. Leon; Mari O. Brady; Deborah Rodriguez; Madison P. McReynolds; Junghun Kweon; Amy E. Neely; Laura A. Blumensaadt; Patric J. Ho; Xiaomin Bao

doi:10.1038/s41467-022-32098-2

Nature Communications (Jul 2022)

CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors

Sarah M. Lloyd,
Daniel B. Leon,
Mari O. Brady,
Deborah Rodriguez,
Madison P. McReynolds,
Junghun Kweon,
Amy E. Neely,
Laura A. Blumensaadt,
Patric J. Ho,
Xiaomin Bao

Affiliations

Sarah M. Lloyd: Department of Molecular Biosciences, Northwestern University
Daniel B. Leon: Department of Molecular Biosciences, Northwestern University
Mari O. Brady: Department of Molecular Biosciences, Northwestern University
Deborah Rodriguez: Department of Molecular Biosciences, Northwestern University
Madison P. McReynolds: Department of Molecular Biosciences, Northwestern University
Junghun Kweon: Department of Molecular Biosciences, Northwestern University
Amy E. Neely: Department of Molecular Biosciences, Northwestern University
Laura A. Blumensaadt: Department of Molecular Biosciences, Northwestern University
Patric J. Ho: Department of Molecular Biosciences, Northwestern University
Xiaomin Bao: Department of Molecular Biosciences, Northwestern University

DOI: https://doi.org/10.1038/s41467-022-32098-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Epidermal progenitors are poised for differentiation, which allows for continual balance of self-renewal and differentiation. Here they show that the Super Elongation Complex regulates this process through direct regulation of a set of rapid response genes that involves a CDK9 activity switch.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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