Frontiers in Physiology (Aug 2022)
Time Domains of Hypoxia Responses and -Omics Insights
- James J. Yu,
- Amy L. Non,
- Erica C. Heinrich,
- Wanjun Gu,
- Wanjun Gu,
- Joe Alcock,
- Esteban A. Moya,
- Elijah S. Lawrence,
- Michael S. Tift,
- Katie A. O'Brien,
- Katie A. O'Brien,
- Jay F. Storz,
- Anthony V. Signore,
- Jane I. Khudyakov,
- William K. Milsom,
- Sean M. Wilson,
- Cynthia M. Beall,
- Francisco C. Villafuerte,
- Tsering Stobdan,
- Colleen G. Julian,
- Lorna G. Moore,
- Mark M. Fuster,
- Jennifer A. Stokes,
- Richard Milner,
- John B. West,
- Jiao Zhang,
- John Y. Shyy,
- Ainash Childebayeva,
- José Pablo Vázquez-Medina,
- Luu V. Pham,
- Omar A. Mesarwi,
- James E. Hall,
- Zachary A. Cheviron,
- Jeremy Sieker,
- Arlin B. Blood,
- Jason X. Yuan,
- Graham R. Scott,
- Brinda K. Rana,
- Brinda K. Rana,
- Paul J. Ponganis,
- Atul Malhotra,
- Frank L. Powell,
- Tatum S. Simonson
Affiliations
- James J. Yu
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Amy L. Non
- Department of Anthropology, Division of Social Sciences, University of California, San Diego, La Jolla, CA, United States
- Erica C. Heinrich
- Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, United States
- Wanjun Gu
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Wanjun Gu
- Herbert Wertheim School of Public Health and Longevity Sciences, University of California, San Diego, La Jolla, CA, United States
- Joe Alcock
- Department of Emergency Medicine, University of New Mexico, Albuquerque, MX, United States
- Esteban A. Moya
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Elijah S. Lawrence
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Michael S. Tift
- Department of Biology and Marine Biology, College of Arts and Sciences, University of North Carolina Wilmington, Wilmington, NC, United States
- Katie A. O'Brien
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Katie A. O'Brien
- Department of Physiology, Development and Neuroscience, Faculty of Biology, School of Biological Sciences, University of Cambridge, Cambridge, ENG, United Kingdom
- Jay F. Storz
- School of Biological Sciences, College of Arts and Sciences, University of Nebraska-Lincoln, Lincoln, IL, United States
- Anthony V. Signore
- School of Biological Sciences, College of Arts and Sciences, University of Nebraska-Lincoln, Lincoln, IL, United States
- Jane I. Khudyakov
- Department of Biological Sciences, University of the Pacific, Stockton, CA, United States
- William K. Milsom
- 0Department of Zoology, Vancouver, BC, Canada
- Sean M. Wilson
- 1Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda, CA, United States
- Cynthia M. Beall
- 2Department of Anthropology, Cleveland, OH, United States
- Francisco C. Villafuerte
- 3Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno, Lima, Peru
- Tsering Stobdan
- 4Department of Pediatrics, San Diego, CA, United States
- Colleen G. Julian
- 5School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
- Lorna G. Moore
- 6Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Aurora, CO, United States
- Mark M. Fuster
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Jennifer A. Stokes
- 7Department of Kinesiology, Southwestern University, Georgetown, TX, United States
- Richard Milner
- 8San Diego Biomedical Research Institute, San Diego, CA, United States
- John B. West
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Jiao Zhang
- 9Department of Medicine, UC San Diego School of Medicine, San Diego, CA, United States
- John Y. Shyy
- 9Department of Medicine, UC San Diego School of Medicine, San Diego, CA, United States
- Ainash Childebayeva
- 0Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
- José Pablo Vázquez-Medina
- 1Department of Integrative Biology, College of Letters and Science, University of California, Berkeley, Berkeley, CA, United States
- Luu V. Pham
- 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, Johns Hopkins Medicine, Baltimore, MD, United States
- Omar A. Mesarwi
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- James E. Hall
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Zachary A. Cheviron
- 3Division of Biological Sciences, College of Humanities and Sciences, University of Montana, Missoula, MT, United States
- Jeremy Sieker
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Arlin B. Blood
- 4Department of Pediatrics Division of Neonatology, School of Medicine, Loma Linda University, Loma Linda, CA, United States
- Jason X. Yuan
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Graham R. Scott
- 5Department of Pediatrics Division of Neonatology, School of Medicine, Loma Linda University, Loma Linda, CA, United States
- Brinda K. Rana
- 6Moores Cancer Center, UC San Diego, La Jolla, CA, United States
- Brinda K. Rana
- 7Department of Psychiatry, UC San Diego, La Jolla, CA, United States
- Paul J. Ponganis
- 8Center for Marine Biotechnology and Biomedicine, La Jolla, CA, United States
- Atul Malhotra
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Frank L. Powell
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- Tatum S. Simonson
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States
- DOI
- https://doi.org/10.3389/fphys.2022.885295
- Journal volume & issue
-
Vol. 13
Abstract
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.
Keywords
