Case Reports in Medicine (Jan 2023)

Successful Treatment of Respiratory Failure in a Patient with Prader-Willi Syndrome with Noninvasive Ventilation with AVAPS

  • Nauras Hwig,
  • Montserrat Diaz-Abad,
  • Victor T. Peng,
  • Jennifer Y. So,
  • Anayansi Lasso-Pirot

DOI
https://doi.org/10.1155/2023/9925144
Journal volume & issue
Vol. 2023

Abstract

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Prader-Willi syndrome (PWS) is the most prevalent syndromic form of obesity, which starts during early childhood in the setting of hyperphagia. Due to the development of obesity, there is a high prevalence of obstructive sleep apnea (OSA) among these patients. This case report presents a patient with PWS with morbid obesity, severe OSA, and obesity hypoventilation syndrome admitted to the hospital for hypoxemic and hypercapnic respiratory failure. Noninvasive ventilation (NIV) with average volume-assured pressure support, a newer NIV modality, was used successfully to treat this patient, achieving major clinical and gas exchange improvement both during the hospitalization and long term after discharge.