Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

Abstract

APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytidine deaminase that restricts HIV-1. Here the authors provide molecular insights into A3G substrate recognition by determining the 1.86 Å resolution crystal structure of its catalytic domain bound to ssDNA.