Early detection of acute ischemic stroke using Contrast-enhanced electrical impedance tomography perfusion

Weirui Zhang; Yang Jiao; Tao Zhang; Xuechao Liu; Jianan Ye; Yuyan Zhang; Bin Yang; Meng Dai; Xuetao Shi; Feng Fu; Liang Wang; Canhua Xu

NeuroImage: Clinical (Jan 2023)

Early detection of acute ischemic stroke using Contrast-enhanced electrical impedance tomography perfusion

Weirui Zhang,
Yang Jiao,
Tao Zhang,
Xuechao Liu,
Jianan Ye,
Yuyan Zhang,
Bin Yang,
Meng Dai,
Xuetao Shi,
Feng Fu,
Liang Wang,
Canhua Xu

Affiliations

Weirui Zhang: Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, People’s Republic of China; Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China
Yang Jiao: Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, Xi’an 710032, People’s Republic of China
Tao Zhang: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China; Drug and Instrument Supervision and Inspection Station, Xining Joint Logistics Support Center, Lanzhou 730050, People’s Republic of China
Xuechao Liu: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China
Jianan Ye: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China
Yuyan Zhang: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China
Bin Yang: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China
Meng Dai: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China
Xuetao Shi: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China
Feng Fu: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China
Liang Wang: Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, Xi’an 710032, People’s Republic of China
Canhua Xu: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China; Shaanxi Key Laboratory for Bioelectromagnetic Detection and Intelligent Perception, Xi’an 710032, People’s Republic of China; Corresponding author at: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China.

Journal volume & issue: Vol. 39
p. 103456

Abstract

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A cerebral contrast-enhanced electrical impedance tomography perfusion method is developed for acute ischemic stroke during intravenous thrombolytic therapy. Several clinical contrast agents with stable impedance characteristics and high-conductivity contrast were screened experimentally as electrical impedance contrast agent candidates. The electrical impedance tomography perfusion method was tested on rabbits with focal cerebral infarction, and its capability for early detection was verified based on perfusion images. The experimental results showed that ioversol 350 performed significantly better as an electrical impedance contrast agent than other contrast agents (p < 0.01). Additionally, perfusion images of focal cerebral infarction in rabbits confirmed that the electrical impedance tomography perfusion method could accurately detect the location and area of different cerebral infarction lesions (p < 0.001). Therefore, the cerebral contrast-enhanced electrical impedance tomography perfusion method proposed herein combines traditional, dynamic continuous imaging with rapid detection and could be applied as an early, rapid-detection, auxiliary, bedside imaging method for patients after a suspected ischemic stroke in both prehospital and in-hospital settings.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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