Bangladesh Journal of Pharmacology (May 2012)

Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt

  • Mohammad Shoeb,
  • Paul Kong Thoo-Lin,
  • Nilufar Nahar

DOI
https://doi.org/10.3329/bjp.v7i1.10507
Journal volume & issue
Vol. 7, no. 1

Abstract

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Endophytic microorganisms are fungi or bacteria that live inside the healthy tissues of the host plants causing no apparent symptoms of diseases. Five endophytic fungal strains labeled as IR-1, IR-2, IR-4, IR-6 and IR-7 (identified as Penicillium thiomii) were isolated from the medicinal plant of Terminalia chebula Retz by culture and sub-culture. The ethyl acetate extract of fungal strains, IR-4, IR-6 and IR-7 inhibited the growth of CaCo-2 colon cancer cell lines in MTT assay with IC50 values of 55, 44 and 67 µg/mL, respectively.

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