Communications Biology (Nov 2022)
Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer
- Lidan Hou,
- Yichao Hou,
- Yu Liang,
- Baiyu Chen,
- Xintian Zhang,
- Yu Wang,
- Kun Zhou,
- Ting Zhong,
- Bohan Long,
- Wenjing Pang,
- Lei Wang,
- Xu Han,
- Linjing Li,
- Ci Xu,
- Isabelle Gross,
- Christian Gaiddon,
- Wei Fu,
- Han Yao,
- Xiangjun Meng
Affiliations
- Lidan Hou
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Yichao Hou
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Yu Liang
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Baiyu Chen
- Department of Medicinal Chemistry, School of Pharmacy, Fudan University
- Xintian Zhang
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Yu Wang
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Kun Zhou
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Ting Zhong
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Bohan Long
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Wenjing Pang
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Lei Wang
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Xu Han
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Linjing Li
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Ci Xu
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Isabelle Gross
- INSERM UMR_S1113, IRFAC
- Christian Gaiddon
- INSERM UMR_S1113, IRFAC
- Wei Fu
- Department of Medicinal Chemistry, School of Pharmacy, Fudan University
- Han Yao
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Xiangjun Meng
- Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-04191-1
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
A peptide that specifically targets amino acid transporter SLC1A5 in colorectal cancer cells is identified and conjugated with camptothecin to show selective cytotoxicity to colorectal cancer cells in preclinical models.
