Haematologica (Jun 2007)

Deregulated over expression of FOXP1 protein in diffuse large B-cell lymphoma does not occur as a result of gene rearrangement

  • Sharon L. Barrans,
  • James A.L. Fenton,
  • Roland Ventura,
  • Alex Smith,
  • Alison H. Banham,
  • Andrew S. Jack

DOI
https://doi.org/10.3324/haematol.10656
Journal volume & issue
Vol. 92, no. 6

Abstract

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Strong uniform expression of FOXP1 protein occurs in a subgroup of non-germinal centre (GC) diffuse large B-cell lymphomas (DLBCL). We have investigated gene rearrangement as a potential mechanism for deregulated expression of FOXP1 however, using FISH FOXP1 translocations were not found in any case with over-expression of the protein.