PLoS ONE (Jan 2019)

Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia.

  • Makiko Omori,
  • Tetsuo Kondo,
  • Hikaru Tagaya,
  • Yumika Watanabe,
  • Hiroko Fukasawa,
  • Masataka Kawai,
  • Kumiko Nakazawa,
  • Akihiko Hashi,
  • Shuji Hirata

DOI
https://doi.org/10.1371/journal.pone.0221088
Journal volume & issue
Vol. 14, no. 8
p. e0221088

Abstract

Read online

ObjectivesTo investigate the use of imaging methods for predicting carcinogenesis in lobular endocervical glandular hyperplasia (LEGH).MethodsWe retrospectively analyzed preoperative images on transvaginal sonography and magnetic resonance imaging (MRI) in 23 cases with histologically diagnosed LEGH.ResultsShape of cervical multicystic lesions on MR images could be divided into two types the flower-type with many small cysts surrounded by larger cysts, and the raspberry-type with many tiny, closely aggregated cysts. Six (46%) of 13 cases had raspberry-type lesions that were not detected on transvaginal sonography but were seen on MRI. Adenocarcinoma in situ (AIS) was identified in 4 postmenopausal women with raspberry-type lesions during the follow-up periods. In these cases, cytologic examination by targeted endocervical sampling using sonography enabled early detection of AIS.ConclusionsMRI and cytologic examination by targeted endocervical sampling may be very useful for predicting carcinogenesis in LEGH.