Prognosis in Myelodysplastic Syndromes: The Clinical Challenge of Genomic Integration

Abstract

Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic neoplasms characterized by ineffective hematopoiesis and myelodysplasia with a variable spectrum of clinical–biological features that can be used to build a prognostic estimation. This review summarizes the current most widely used prognostic scoring systems and gives a general view of the prognostic impact of somatic mutations in MDS patients.

Keywords

• prognostic impact
• clinical–genetic alterations
• myelodysplastic syndrome