Nature Communications (Oct 2022)

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine

  • David Alarcón-Alarcón,
  • David Cabañero,
  • Jorge de Andrés-López,
  • Magdalena Nikolaeva-Koleva,
  • Simona Giorgi,
  • Gregorio Fernández-Ballester,
  • Asia Fernández-Carvajal,
  • Antonio Ferrer-Montiel

DOI
https://doi.org/10.1038/s41467-022-33835-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

A mouse model of chronic migraine reveals that males recover normal sensitivity before than females. This antinociception requires TRPM8 expression and presence of testosterone, which elicits currents and calcium transients via human and murine TRPM8.