Nature Communications (Aug 2016)

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

  • Andrew L. Young,
  • Grant A. Challen,
  • Brenda M. Birmann,
  • Todd E. Druley

DOI
https://doi.org/10.1038/ncomms12484
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 7

Abstract

Read online

Clonal haematopoiesis has been thought to occur in less than 10% of individuals younger than 70 years old. Here, the authors use an error corrected next-generation sequencing method to find clonal haematopoiesis in the peripheral blood of 19 of 20 healthy 50–70 year old individuals.