Nature Communications (Aug 2022)
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
- Chien-Wen Chen,
- Bo-Jhih Guan,
- Mohammed R. Alzahrani,
- Zhaofeng Gao,
- Long Gao,
- Syrena Bracey,
- Jing Wu,
- Cheikh A. Mbow,
- Raul Jobava,
- Leena Haataja,
- Ajay H. Zalavadia,
- Ashleigh E. Schaffer,
- Hugo Lee,
- Thomas LaFramboise,
- Ilya Bederman,
- Peter Arvan,
- Clayton E. Mathews,
- Ivan C. Gerling,
- Klaus H. Kaestner,
- Boaz Tirosh,
- Feyza Engin,
- Maria Hatzoglou
Affiliations
- Chien-Wen Chen
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Bo-Jhih Guan
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Mohammed R. Alzahrani
- Department of Biochemistry, Case Western Reserve University
- Zhaofeng Gao
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Long Gao
- Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine
- Syrena Bracey
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Jing Wu
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Cheikh A. Mbow
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Raul Jobava
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Leena Haataja
- The Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center
- Ajay H. Zalavadia
- Lerner Research Institute, Cleveland Clinic
- Ashleigh E. Schaffer
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Hugo Lee
- Department of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public Health
- Thomas LaFramboise
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Ilya Bederman
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Peter Arvan
- The Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center
- Clayton E. Mathews
- Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine
- Ivan C. Gerling
- Department of Medicine, University of Tennessee
- Klaus H. Kaestner
- Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine
- Boaz Tirosh
- Department of Biochemistry, Case Western Reserve University
- Feyza Engin
- Department of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public Health
- Maria Hatzoglou
- Department of Genetics and Genome Sciences, Case Western Reserve University
- DOI
- https://doi.org/10.1038/s41467-022-32425-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Pancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogenesis
