Oxidation of phenyl alanine by pyridinium chlorochromate in acidic DMF–water medium: A kinetic study

Abstract

The kinetics of oxidation of phenyl alanine by pyridinium chlorochromate in DMF–water (70:30%) mixture in presence of perchloric acid leads to the formation of corresponding aldehyde. The reaction is of first order each in [PCC], [HClO4] and [AA]. Michaelis–Menten type kinetics was observed with phenyl alanine. The reaction rates were determined at different temperatures [25, 30, 35, 40, 45, 50 °C] and the activation parameters were calculated. The reaction does not induce polymerization of acrylonitrile. With an increase in the amount of DMF in its aqueous mixture, the rate increases. A suitable mechanism for the reaction was postulated.

Keywords

• N,N-Dimethyl formamide (DMF)
• Kinetics
• Michaelis–Menten
• Oxidation
• Phenyl alanine
• Pyridinium chlorochromate (PCC)