Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice

Matthew A. Cottam; Heather L. Caslin; Nathan C. Winn; Alyssa H. Hasty

doi:10.1038/s41467-022-30646-4

Nature Communications (May 2022)

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice

Matthew A. Cottam,
Heather L. Caslin,
Nathan C. Winn,
Alyssa H. Hasty

Affiliations

Matthew A. Cottam: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine
Heather L. Caslin: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine
Nathan C. Winn: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine
Alyssa H. Hasty: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-30646-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Adipose immune cells contribute to obesity-related disease, but less is known about weight cycling. Here, authors show that weight loss reduces diabetes risk, but inflammatory adipose immune cell populations persist and may contribute to worsened diabetes risk upon weight regain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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