Nature Communications (Jan 2020)

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice

  • Yun Rose Li,
  • Kyle D. Halliwill,
  • Cassandra J. Adams,
  • Vivek Iyer,
  • Laura Riva,
  • Rashid Mamunur,
  • Kuang-Yu Jen,
  • Reyno del Rosario,
  • Erik Fredlund,
  • Gillian Hirst,
  • Ludmil B. Alexandrov,
  • David Adams,
  • Allan Balmain

DOI
https://doi.org/10.1038/s41467-019-14261-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Mutational signatures induced by ionising radiation remain largely unexplored. Here in TP53 mutant mice, the authors characterise the genomic landscape of tumours induced by high- and low-energy radiation.