Nature Communications (Nov 2021)

Nuclear S-nitrosylation impacts tissue regeneration in zebrafish

  • Gianfranco Matrone,
  • Sung Yun Jung,
  • Jong Min Choi,
  • Antrix Jain,
  • Hon-Chiu Eastwood Leung,
  • Kimal Rajapakshe,
  • Cristian Coarfa,
  • Julie Rodor,
  • Martin A. Denvir,
  • Andrew H. Baker,
  • John P. Cooke

DOI
https://doi.org/10.1038/s41467-021-26621-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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The role of the post-translational modifications in tissue regeneration is still not clearly understood. Here, the authors show that many nuclear proteins change S-nitrosylation state in the regenerating zebrafish tailfin, highlighting the importance of Kdm1a S-nitrosylation in the repair process.