Altered basal ganglia network integration in schizophrenia

Mingjun eDuan; Mingjun eDuan; Xi eChen; Hui eHe; Yuchao eJiang; Sisi eJiang; Qiankun eXie; Yongxiu eLai; Cheng eLuo; Dezhong eYao

doi:10.3389/fnhum.2015.00561

Frontiers in Human Neuroscience (Oct 2015)

Affiliations

Mingjun eDuan: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China
Mingjun eDuan: The Fourth People’s Hospital Chengdu
Xi eChen: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China
Hui eHe: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China
Yuchao eJiang: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China
Sisi eJiang: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China
Qiankun eXie: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China
Yongxiu eLai: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China
Cheng eLuo: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China
Dezhong eYao: Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China

DOI: https://doi.org/10.3389/fnhum.2015.00561
Journal volume & issue: Vol. 9

Abstract

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The basal ganglia involve in a range of functions which are disturbed in schizophrenia. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional connectivity in the bilateral caudate nucleus in schizophrenia. Further, the caudate nucleus in schizophrenia showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number. ChiCTR-RCS-14004878.

Published in Frontiers in Human Neuroscience

ISSN: 1662-5161 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/human_neuroscience

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