Frontiers in Cellular Neuroscience (Dec 2022)
Protective effect of anakinra on audiovestibular function in a murine model of endolymphatic hydrops
- Na Zhang,
- Na Zhang,
- Na Zhang,
- Na Li,
- Na Li,
- Na Li,
- Siyue Wang,
- Siyue Wang,
- Siyue Wang,
- Wandi Xu,
- Wandi Xu,
- Wandi Xu,
- Jiahui Liu,
- Jiahui Liu,
- Jiahui Liu,
- Yafeng Lyu,
- Yafeng Lyu,
- Yafeng Lyu,
- Xiaofei Li,
- Xiaofei Li,
- Xiaofei Li,
- Yongdong Song,
- Yongdong Song,
- Yongdong Song,
- Ligang Kong,
- Ligang Kong,
- Ligang Kong,
- Yalan Liu,
- Yalan Liu,
- Yalan Liu,
- Jia Guo,
- Jia Guo,
- Jia Guo,
- Zhaomin Fan,
- Zhaomin Fan,
- Zhaomin Fan,
- Daogong Zhang,
- Daogong Zhang,
- Daogong Zhang,
- Haibo Wang,
- Haibo Wang,
- Haibo Wang
Affiliations
- Na Zhang
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Na Zhang
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Na Zhang
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Na Li
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Na Li
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Na Li
- Center of Clinical Laboratory, Shandong Second Provincial General Hospital, Jinan, Shandong, China
- Siyue Wang
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Siyue Wang
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Siyue Wang
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Wandi Xu
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Wandi Xu
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Wandi Xu
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Jiahui Liu
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Jiahui Liu
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Jiahui Liu
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Yafeng Lyu
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Yafeng Lyu
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Yafeng Lyu
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Xiaofei Li
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Xiaofei Li
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Xiaofei Li
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Yongdong Song
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Yongdong Song
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Yongdong Song
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Ligang Kong
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Ligang Kong
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Ligang Kong
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Yalan Liu
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Yalan Liu
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Yalan Liu
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Jia Guo
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Jia Guo
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Jia Guo
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Zhaomin Fan
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Zhaomin Fan
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Zhaomin Fan
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Daogong Zhang
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Daogong Zhang
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Daogong Zhang
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- Haibo Wang
- Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China
- Haibo Wang
- Shandong Provincial Vertigo and Dizziness Medical Center, Jinan, Shandong, China
- Haibo Wang
- Laboratory of Vertigo Disease, Shandong Second Provincial General Hospital, Shandong Institute of Otorhinolaryngology, Jinan, Shandong, China
- DOI
- https://doi.org/10.3389/fncel.2022.1088099
- Journal volume & issue
-
Vol. 16
Abstract
IntroductionMénière’s disease (MD), a common disease in the inner ear, is characterized by an increase in endolymph in the cochlear duct and vestibular labyrinth. The pathophysiology of the condition appears to be the immune response. Studies have shown that basal levels of the IL-1β increased in some MD patients.MethodsHere, we used a murine model of endolymphatic hydrops (EH) to study the effect of anakinra on auditory and vestibular function. Mice were intraperitoneal injected with anakinra or saline before LPS by postauricular injection. Weight and disease severity were measured, histologic changes in auditory were assessed, and inflammation state was evaluated.ResultsWe found that anakinra therapy reduced LPS-induced EH, alleviated LPS-induced hearing loss and vestibular dysfunction, and inhibited the expression of the inflammatory cytokines and macrophage infiltration in the cochlea of mice. We further demonstrated that anakinra ameliorated the disorganization and degeneration of myelin sheath, and reduced the neuron damage in cochlea of EH mice.DiscussionConsequently, anakinra contributes to a promising therapeutic approach to MD, by restricting EH, alleviating auditory and vestibular function, inhibiting inflammation of the inner ear and protecting the cochlear nerve. Further investigations are needed to assess the potential therapeutic benefits of anakinra in patients with MD.
Keywords
