New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i>

Abstract

Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (1–7), along with the known analogue cladosporiumin D (8), were obtained from the extract of the deep-sea-derived fungus Lecanicillium fusisporum GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds 1, 2, 5–7 exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC50 values range of 18.49–30.19 μM.

Keywords

• tetramic acid derivatives
• deep-sea fungus
• clavipitacae
• <i>Lecanicillium fusisporum</i>
• anti-inflammatory activity