Novel Bioactive Titanate Layers Formed on Ti Metal and Its Alloys by Chemical Treatments

Abstract

Sodium titanate formed on Ti metal by NaOH and heat treatments induces apatite formation on its surface in a body environment and bonds to living bone. These treatments have been applied to porous Ti metal in artificial hip joints, and have been used clinically in Japan since 2007. Calcium titanate formed on Ti-15Zr-4Nb-4Ta alloy by NaOH, CaCl2, heat, and water treatments induces apatite formation on its surface in a body environment. Titanium oxide formed on porous Ti metal by NaOH, HCl, and heat treatments exhibits osteoinductivity as well as osteoconductivity. This is now under clinical tests for application to a spinal fusion device.

Keywords

• bioactive
• titanate
• osteoinduction
• osteoconduction
• Ti metal
• Ti-based alloy
• artificial joint
• spinal fusion device
• apatite