The Relationship Between Postmenopausal Osteoporosis and Autophagic Gene Polymorphisms

Abstract

Objective:This study investigates the role of ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 gene polymorphisms, which are involved in autophagosome formation, in the susceptibility to postmenopausal osteoporosis (PMO) disease.Materials and Methods:Hundred PMO patients and 100 healthy controls without PMO were included into the study. The distribution of the genotypes of ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 polymorphisms in these subjects were analyzed using the TaqMan 5´-exonuclease allelic discrimination assay.Results:The T allele was detected more frequent among patients with osteoporosis (53%) of the ATG10 rs1864183 polymorphism. C allele in ATG16L1 rs2241880 polymorphism in the group of patients with osteoporosis was observed more frequent (56.5%). Besides, the G allele of the ATG5 rs2245214 polymorphism was identified more common in PMO (34%) than in control group. However, no significant difference were detected in genotype and allele frequencies in terms of these polymorphisms between the patient and the control groups (p>0.05).Conclusion:In summary, the results of our study do not support the hypothesis that ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 polymorphisms influence the predisposition for osteoporosis in postmenopausal women.

Keywords

• autophagy
• gene polymorphism
• postmenopausal osteoporosis