Nature Communications (Jun 2021)
Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis
- Yuki Horisawa-Takada,
- Chisato Kodera,
- Kazumasa Takemoto,
- Akihiko Sakashita,
- Kenichi Horisawa,
- Ryo Maeda,
- Ryuki Shimada,
- Shingo Usuki,
- Sayoko Fujimura,
- Naoki Tani,
- Kumi Matsuura,
- Tomohiko Akiyama,
- Atsushi Suzuki,
- Hitoshi Niwa,
- Makoto Tachibana,
- Takashi Ohba,
- Hidetaka Katabuchi,
- Satoshi H. Namekawa,
- Kimi Araki,
- Kei-Ichiro Ishiguro
Affiliations
- Yuki Horisawa-Takada
- Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University
- Chisato Kodera
- Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University
- Kazumasa Takemoto
- Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University
- Akihiko Sakashita
- Department of Molecular Biology, Keio University School of Medicine
- Kenichi Horisawa
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Ryo Maeda
- Graduate School of Frontier Biosciences, Osaka University
- Ryuki Shimada
- Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University
- Shingo Usuki
- Liaison Laboratory Research Promotion Center, IMEG, Kumamoto University
- Sayoko Fujimura
- Liaison Laboratory Research Promotion Center, IMEG, Kumamoto University
- Naoki Tani
- Liaison Laboratory Research Promotion Center, IMEG, Kumamoto University
- Kumi Matsuura
- Department of Pluripotent Stem Cell Biology, IMEG, Kumamoto University
- Tomohiko Akiyama
- Department of Systems Medicine, Keio University School of Medicine
- Atsushi Suzuki
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Hitoshi Niwa
- Department of Pluripotent Stem Cell Biology, IMEG, Kumamoto University
- Makoto Tachibana
- Graduate School of Frontier Biosciences, Osaka University
- Takashi Ohba
- Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University
- Hidetaka Katabuchi
- Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University
- Satoshi H. Namekawa
- Department of Microbiology and Molecular Genetics, University of California
- Kimi Araki
- Institute of Resource Development and Analysis, and Center for Metabolic Regulation of Healthy Aging, Kumamoto University
- Kei-Ichiro Ishiguro
- Department of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University
- DOI
- https://doi.org/10.1038/s41467-021-23378-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The authors add to our knowledge of the transcriptional regulation of the meiotic program in mice spermatocytes, showing ZFP541 regulates meiotic prophase and transition to the division phase by being the target for upstream factors MEIOSIN/STRA8.
