Antifungal Styryloquinolines as <i>Candida albicans</i> Efflux Pump Inhibitors: Styryloquinolines are ABC Transporter Inhibitors

Abstract

Styrylquinolines are heterocyclic compounds that are known for their antifungal and antimicrobial activity. Metal complexation through hydroxyl groups has been claimed to be a plausible mechanism of action for these types of compounds. A series of novel structures with protected hydroxyl groups have been designed and synthesized to verify the literature data. Their antifungal activity against wild-type Candida albicans strain and mutants with silenced efflux pumps activity has been determined. Combinations with fluconazole revealed synergistic interactions that were dependent on the substitution pattern. These results open a new route for designing active antifungal agents on a styrylquinoline scaffold.

Keywords

• styrylquinolines
• <i>candida albicans</i>
• abc transporters
• cdr1p