Spatiotemporal control of coacervate formation within liposomes

Siddharth Deshpande; Frank Brandenburg; Anson Lau; Mart G. F. Last; Willem Kasper Spoelstra; Louis Reese; Sreekar Wunnava; Marileen Dogterom; Cees Dekker

doi:10.1038/s41467-019-09855-x

Nature Communications (Apr 2019)

Spatiotemporal control of coacervate formation within liposomes

Siddharth Deshpande,
Frank Brandenburg,
Anson Lau,
Mart G. F. Last,
Willem Kasper Spoelstra,
Louis Reese,
Sreekar Wunnava,
Marileen Dogterom,
Cees Dekker

Affiliations

Siddharth Deshpande: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology
Frank Brandenburg: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology
Anson Lau: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology
Mart G. F. Last: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology
Willem Kasper Spoelstra: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology
Louis Reese: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology
Sreekar Wunnava: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology
Marileen Dogterom: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology
Cees Dekker: Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology

DOI: https://doi.org/10.1038/s41467-019-09855-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

The understanding of liquid-liquid phase separation is crucial to cell biology and benefits from cell-mimicking in vitro assays. Here, the authors develop a microfluidic platform to study coacervate formation inside liposomes and show the potential of these hybrid systems to create synthetic cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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