MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types

Khoa Nguyen; Minh N. Tran; Andrew Rivera; Thomas Cheng; Gabrielle O. Windsor; Abraham B. Chabot; Jane E. Cavanaugh; Bridgette M. Collins-Burow; Sean B. Lee; David H. Drewry; Patrick T. Flaherty; Matthew E. Burow

doi:10.31083/j.fbl2705167

Frontiers in Bioscience-Landmark (May 2022)

MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types

Khoa Nguyen,
Minh N. Tran,
Andrew Rivera,
Thomas Cheng,
Gabrielle O. Windsor,
Abraham B. Chabot,
Jane E. Cavanaugh,
Bridgette M. Collins-Burow,
Sean B. Lee,
David H. Drewry,
Patrick T. Flaherty,
Matthew E. Burow

Affiliations

Khoa Nguyen: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
Minh N. Tran: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
Andrew Rivera: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
Thomas Cheng: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
Gabrielle O. Windsor: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
Abraham B. Chabot: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
Jane E. Cavanaugh: Department of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USA
Bridgette M. Collins-Burow: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
Sean B. Lee: Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
David H. Drewry: UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, Chemical Biology and Medicinal Chemistry Division, SGC-UNC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Patrick T. Flaherty: Department of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USA
Matthew E. Burow: Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA

DOI: https://doi.org/10.31083/j.fbl2705167
Journal volume & issue: Vol. 27, no. 5
p. 167

Abstract

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The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases.

Published in Frontiers in Bioscience-Landmark

ISSN: 2768-6701 (Print); 2768-6698 (Online)
Publisher: IMR Press
Country of publisher: Singapore
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (General)
Website: https://www.imrpress.com/journal/FBL

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