Evaluation of the Relationship between Paraoxonase-1 Enzyme Activity, Affected Volume, and Stroke Onset in Acute Ischemic Stroke Patients

Abstract

Acute ischemic stroke has an important place among emergency department admissions. After a rapid diagnosis of the patient admitted with a preliminary diagnosis of stroke, the necessary examination and first intervention should be performed, then diagnostic evaluation should be made. The aim of this study was to investigate whether paraoxonase-1 (PON-1) enzyme activity, measured in patients whose stroke onset is known, is a diagnostic biomarker for stroke by evaluating the relationship between stroke diagnosis, ischemic area volume, and stroke onset. The study included 100 patients over age 18 admitted to the emergency department with acute stroke symptoms, with known stroke onset and diagnosed as acute occlusive cerebrovascular disease within 24 hours, and 100 healthy control subjects. After initial evaluation, computed tomography of the brain and magnetic resonance imaging, PON-1 activity was measured by colorimetric method in patient serum. Comparison of PON-1 levels between the two groups yielded a statistically significant difference. There was a significant decrease in serum PON-1 values in patient group as compared with control group (p<0.001). According to these results, no significant relationship was found between the affected ischemic area of the brain, PON-1, and ischemic volume values. The possible relationship between PON-1 values and stroke onset was compared and no statistically significant difference was found (p=0.311). The relationship between PON-1 enzyme activity and diagnosis of acute ischemic stroke was found to be significant. PON-1 was found to be lower in stroke patients but no correlation was found with ischemic area volume.

Keywords

• Emergency department
• Stroke
• Paraoxonase-1 enzyme activity
• Stroke onset
• Ischemic area volume