Nature Communications (Mar 2023)
The protective role of conjunctival goblet cell mucin sialylation
- Moe Matsuzawa,
- Tomoaki Ando,
- Saaya Fukase,
- Meiko Kimura,
- Yasuharu Kume,
- Takuma Ide,
- Kumi Izawa,
- Ayako Kaitani,
- Mutsuko Hara,
- Eri Nakamura,
- Anna Kamei,
- Akira Matsuda,
- Nobuhiro Nakano,
- Keiko Maeda,
- Norihiro Tada,
- Hideoki Ogawa,
- Ko Okumura,
- Akira Murakami,
- Nobuyuki Ebihara,
- Jiro Kitaura
Affiliations
- Moe Matsuzawa
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Tomoaki Ando
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Saaya Fukase
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Meiko Kimura
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Yasuharu Kume
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Takuma Ide
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Kumi Izawa
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Ayako Kaitani
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Mutsuko Hara
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Eri Nakamura
- Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine
- Anna Kamei
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Akira Matsuda
- Department of Ophthalmology, Juntendo University Graduate School of Medicine
- Nobuhiro Nakano
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Keiko Maeda
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Norihiro Tada
- Center for Biomedical Research Resources, Juntendo University Graduate School of Medicine
- Hideoki Ogawa
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Ko Okumura
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- Akira Murakami
- Department of Ophthalmology, Juntendo University Graduate School of Medicine
- Nobuyuki Ebihara
- Department of Ophthalmology, Juntendo University Urayasu Hospital
- Jiro Kitaura
- Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-37101-y
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Conjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis.
