Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity

Nicholas C. Penney; Derek K. T. Yeung; Isabel Garcia-Perez; Joram M. Posma; Aleksandra Kopytek; Bethany Garratt; Hutan Ashrafian; Gary Frost; Julian R. Marchesi; Sanjay Purkayastha; Lesley Hoyles; Ara Darzi; Elaine Holmes

doi:10.1038/s43856-022-00185-6

Communications Medicine (Oct 2022)

Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity

Nicholas C. Penney,
Derek K. T. Yeung,
Isabel Garcia-Perez,
Joram M. Posma,
Aleksandra Kopytek,
Bethany Garratt,
Hutan Ashrafian,
Gary Frost,
Julian R. Marchesi,
Sanjay Purkayastha,
Lesley Hoyles,
Ara Darzi,
Elaine Holmes

Affiliations

Nicholas C. Penney: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Derek K. T. Yeung: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Isabel Garcia-Perez: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Joram M. Posma: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Aleksandra Kopytek: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Bethany Garratt: Department of Surgery and Cancer, Faculty of Medicine, Imperial College London
Hutan Ashrafian: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Gary Frost: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Julian R. Marchesi: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Sanjay Purkayastha: Department of Surgery and Cancer, Faculty of Medicine, Imperial College London
Lesley Hoyles: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
Ara Darzi: Department of Surgery and Cancer, Faculty of Medicine, Imperial College London
Elaine Holmes: Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London

DOI: https://doi.org/10.1038/s43856-022-00185-6
Journal volume & issue: Vol. 2, no. 1
pp. 1 – 18

Abstract

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Penney et al. conduct microbial and metabolic profiling in people with obesity, with or without type 2 diabetes, undergoing two types of bariatric surgery. Integrative analysis identifies multi-omic signatures associated with response to surgery, body mass index, and glycaemic control.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

About the journal