Mediterranean Journal of Hematology and Infectious Diseases (Jun 2009)

COAGULOPATHY IN BETA-THALASSEMIA: CURRENT UNDERSTANDING AND FUTURE PERSPECTIVES

  • Alessia Marcon,
  • Khaled M. Musallam,
  • M. Domenica Cappellini,
  • Ali Taher

Journal volume & issue
Vol. 1, no. 1
pp. e2009029 – e2009029

Abstract

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<p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-layout-grid-align: none;"><span style="line-height: 200%; font-family: ";Times New Roman";,";serif";; font-size: 12pt;" lang="EN-US">As the life expectancy of &beta;-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.</span></p>

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