Nature Communications (Mar 2019)

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

  • Jong-Sung Park,
  • Yumin Oh,
  • Yong Joo Park,
  • Ogyi Park,
  • Hoseong Yang,
  • Stephanie Slania,
  • Laura K. Hummers,
  • Ami A. Shah,
  • Hyoung-Tae An,
  • Jiyeon Jang,
  • Maureen R. Horton,
  • Joseph Shin,
  • Harry C. Dietz,
  • Eric Song,
  • Dong Hee Na,
  • Eun Ji Park,
  • Kwangmeyung Kim,
  • Kang Choon Lee,
  • Viktor V. Roschke,
  • Justin Hanes,
  • Martin G. Pomper,
  • Seulki Lee

DOI
https://doi.org/10.1038/s41467-019-09101-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Dermal myofibroblasts are responsible for fibrosis development in scleroderma. Here the authors show that a bioengineered recombinant human TRAIL ligand reverses established fibrosis in mouse models of scleroderma by targeting the death receptor 5 and inducing apoptosis of myofibroblasts.