Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258

Shayla Hesse; Natalia Malachowa; Adeline R. Porter; Brett Freedman; Scott D. Kobayashi; Donald J. Gardner; Dana P. Scott; Sankar Adhya; Frank R. DeLeo

doi:10.1128/mBio.00034-21

mBio (Feb 2021)

Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258

Shayla Hesse,
Natalia Malachowa,
Adeline R. Porter,
Brett Freedman,
Scott D. Kobayashi,
Donald J. Gardner,
Dana P. Scott,
Sankar Adhya,
Frank R. DeLeo

Affiliations

Shayla Hesse: ORCiD; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Natalia Malachowa: Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Adeline R. Porter: Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Brett Freedman: Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Scott D. Kobayashi: Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Donald J. Gardner: Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Dana P. Scott: Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Sankar Adhya: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Frank R. DeLeo: Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

DOI: https://doi.org/10.1128/mBio.00034-21
Journal volume & issue: Vol. 12, no. 1

Abstract

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Infections caused by multidrug-resistant K. pneumoniae

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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