Nature Communications (May 2022)
SARS-CoV-2 accessory proteins reveal distinct serological signatures in children
- Asmaa Hachim,
- Haogao Gu,
- Otared Kavian,
- Masashi Mori,
- Mike Y. W. Kwan,
- Wai Hung Chan,
- Yat Sun Yau,
- Susan S. Chiu,
- Owen T. Y. Tsang,
- David S. C. Hui,
- Chris K. P. Mok,
- Fionn N. L. Ma,
- Eric H. Y. Lau,
- Gaya K. Amarasinghe,
- Abraham J. Qavi,
- Samuel M. S. Cheng,
- Leo L. M. Poon,
- J. S. Malik Peiris,
- Sophie A. Valkenburg,
- Niloufar Kavian
Affiliations
- Asmaa Hachim
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Haogao Gu
- Division of Public Health Laboratory Sciences, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Otared Kavian
- Department of Mathematics, Université de Versailles Saint-Quentin
- Masashi Mori
- Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
- Mike Y. W. Kwan
- Department of Pediatric and Adolescent Medicine, Princess Margaret Hospital, Hospital Authority of Hong Kong
- Wai Hung Chan
- Department of Pediatrics, Queen Elizabeth Hospital, Hospital Authority of Hong Kong
- Yat Sun Yau
- Department of Pediatrics, Queen Elizabeth Hospital, Hospital Authority of Hong Kong
- Susan S. Chiu
- Department of Pediatric and Adolescent Medicine, The University of Hong Kong and Queen Mary Hospital, Hospital Authority of Hong Kong
- Owen T. Y. Tsang
- Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong
- David S. C. Hui
- Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong
- Chris K. P. Mok
- The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong
- Fionn N. L. Ma
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Eric H. Y. Lau
- WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Gaya K. Amarasinghe
- Department of Pathology and Immunology, Washington University School of Medicine in St. Louis
- Abraham J. Qavi
- Department of Pathology and Immunology, Washington University School of Medicine in St. Louis
- Samuel M. S. Cheng
- Division of Public Health Laboratory Sciences, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Leo L. M. Poon
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- J. S. Malik Peiris
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Sophie A. Valkenburg
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Niloufar Kavian
- HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-022-30699-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
The antibody response of children to SARS-CoV-2 is less well studied than in adults. Here Hachim et al. show that children have reduced antibody levels to structural proteins and suggest that the predominance of antibody responses to non-structural proteins can be used to discriminate infection and vaccination.
