Molecular subtypes of ischemic heart disease based on circadian rhythm

Zhaokai Zhou; Ge Zhang; Zhan Wang; Yudi Xu; Hongzhuo Qin; Haonan Zhang; Pengpeng Zhang; Zhengrui Li; Shuai Xu; Xin Tan; Yiyao Zeng; Fengyi Yu; Shanshan Zhu; Le Chang; Youyang Zheng; Xinwei Han

doi:10.1038/s41598-024-65236-5

Scientific Reports (Jun 2024)

Molecular subtypes of ischemic heart disease based on circadian rhythm

Zhaokai Zhou,
Ge Zhang,
Zhan Wang,
Yudi Xu,
Hongzhuo Qin,
Haonan Zhang,
Pengpeng Zhang,
Zhengrui Li,
Shuai Xu,
Xin Tan,
Yiyao Zeng,
Fengyi Yu,
Shanshan Zhu,
Le Chang,
Youyang Zheng,
Xinwei Han

Affiliations

Zhaokai Zhou: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University
Ge Zhang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University
Zhan Wang: Department of Urology, The First Affiliated Hospital of Zhengzhou University
Yudi Xu: Department of Neurology, The First Affiliated Hospital of Zhengzhou University
Hongzhuo Qin: Department of Neurology, The First Affiliated Hospital of Zhengzhou University
Haonan Zhang: Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University
Pengpeng Zhang: Department of Lung Cancer, Tianjin Lung Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital
Zhengrui Li: Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Shuai Xu: Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University
Xin Tan: Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University
Yiyao Zeng: Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University
Fengyi Yu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University
Shanshan Zhu: Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University
Le Chang: School of Medicine, Zhengzhou University
Youyang Zheng: Department of Cardiology, Fuwai Hospital, National Centre for Cardiovascular Diseases, National Clinical Research Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Xinwei Han: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University

DOI: https://doi.org/10.1038/s41598-024-65236-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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Abstract Coronary atherosclerotic heart disease (CAD) is among the most prevalent chronic diseases globally. Circadian rhythm disruption (CRD) is closely associated with the progression of various diseases. However, the precise role of CRD in the development of CAD remains to be elucidated. The Circadian rhythm disruption score (CRDscore) was employed to quantitatively assess the level of CRD in CAD samples. Our investigation revealed a significant association between high CRDscore and adverse prognosis in CAD patients, along with a substantial correlation with CAD progression. Remarkably distinct CRDscore distributions were also identified among various subtypes. In summary, we have pioneered the revelation of the relationship between CRD and CAD at the single-cell level and established reliable markers for the development, treatment, and prognosis of CAD. A deeper understanding of these mechanisms may offer new possibilities for incorporating "the therapy of coronary heart disease based circadian rhythm" into personalized medical treatment regimens.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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Abstract

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