Nature Communications (Nov 2018)
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
- Fangjie Wang,
- Meng Meng,
- Banghui Mo,
- Yao Yang,
- Yan Ji,
- Pei Huang,
- Wenjing Lai,
- Xiaodong Pan,
- Tingting You,
- Hongqin Luo,
- Xiao Guan,
- Yafei Deng,
- Shunzong Yuan,
- Jianhong Chu,
- Michael Namaka,
- Tiffany Hughes,
- Lilin Ye,
- Jianhua Yu,
- Xiaohui Li,
- Youcai Deng
Affiliations
- Fangjie Wang
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Meng Meng
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Banghui Mo
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Yao Yang
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Yan Ji
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Pei Huang
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Wenjing Lai
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Xiaodong Pan
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Tingting You
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Hongqin Luo
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Xiao Guan
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Yafei Deng
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Shunzong Yuan
- Department of Laboratory Medicine, PLA 307 Hospital
- Jianhong Chu
- Institute of Blood and Marrow Transplantation, Soochow University
- Michael Namaka
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Tiffany Hughes
- The Ohio State University Comprehensive Cancer Center and the James Cancer Hospital
- Lilin Ye
- Institute of Immunology, Army Medical University (Third Military Medical University)
- Jianhua Yu
- The Ohio State University Comprehensive Cancer Center and the James Cancer Hospital
- Xiaohui Li
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- Youcai Deng
- Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)
- DOI
- https://doi.org/10.1038/s41467-018-07277-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate cytokine and cellular signaling and modulate NK maturation and effector functions.
