Synthesis, spectral, antimicrobial, and antifertility studies of tetraaza macrocyclic complexes of tin(II)

Abstract

A novel family of tetraazamacrocyclic complexes of Sn(II) has been synthesized by template condensation using 1,9-diaminononane with different dicarboxylic acids (malonic, succinic, glutaric, and adipic). The complexes were characterized by elemental analysis, conductivity measurements, molecular weight determinations, infrared (IR), proton nuclear magnetic resonance (1H NMR), carbon nuclear magnetic resonance (13C NMR), and tin nuclear magnetic resonance (119Sn NMR) spectral studies. The compounds were found to be monomeric in nature, having an octahedral geometry. The in vitro antibacterial activity of macrocyclic complexes against Escherichia coli and Staphylococcus aureus were tested to assess their inhibiting activities. The antifungal activity of starting materials and their metal complexes were studied by screening the compounds against Fusarium oxysporum and Aspergillus niger. The testicular sperm density, sperm morphology, sperm motility, density of cauda epididymis, spermatozoa, and fertility in mating trials and the biochemical parameters of the reproductive organs of the rats were examined and are discussed.

Keywords

• antibacterial activity
• macrocyclic complexes
• monomeric
• octahedral geometry