Journal of Bone and Joint Infection (Jun 2024)

<i>Ureaplasma urealyticum</i> osteomyelitis of the greater trochanter in a patient with multiple sclerosis using ocrelizumab – a case report

  • F. Ruythooren,
  • F. Ruythooren,
  • S. Ghijselings,
  • S. Ghijselings,
  • M. Depypere,
  • W.-J. Metsemakers,
  • W.-J. Metsemakers,
  • L. Henckaerts,
  • L. Henckaerts,
  • N. Noppe,
  • G. Vles,
  • G. Vles

DOI
https://doi.org/10.5194/jbji-9-167-2024
Journal volume & issue
Vol. 9
pp. 167 – 171

Abstract

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Ocrelizumab – a monoclonal anti-CD20 antibody used in treatment of multiple sclerosis (MS) – marks significant progress in treating autoimmune diseases but raises susceptibility to opportunistic infections due to hypogammaglobulinemia. A young MS patient developed osteomyelitis from persistent Ureaplasma urealyticum urethritis, which was diagnosed with specialized polymerase chain reaction and resolved with targeted antibiotics. A multidisciplinary approach is crucial for managing such infections.