Communications Biology (Jan 2023)

Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin

  • Curtis A. Allred,
  • Claire Gormley,
  • Indu Venugopal,
  • Shunzi Li,
  • Michael J. McGuire,
  • Kathlynn C. Brown

DOI
https://doi.org/10.1038/s42003-022-04385-7
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 11

Abstract

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Peptide modification is used to optimize the transport of saporin specifically to cancer cells in vitro and in vivo, where it exerts anti-cancer actions.