Molecular Differentiation of Mycobacterium tuberculosis Strains without IS6110 Insertions

Abstract

By using standard restriction fragment length polymorphism, 6 zero-copy IS6110 Mycobacterium tuberculosis isolates were identified from 1,180 Maryland isolates as part of the National Tuberculosis Genotyping Surveillance Network Project. By using various genotyping methods, we demonstrated that this zero band cluster can be differentiated into six genotypes.

Keywords

• IS6110
• zero band
• Mycobacterium tuberculosis
• molecular epidemiology
• United States