Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics

Cameron S. Fraser; Johan K. E. Spetz; Xingping Qin; Adam Presser; Jonathan Choiniere; Chendi Li; Stacey Yu; Frances Blevins; Aaron N. Hata; Jeffrey W. Miller; Gary A. Bradshaw; Marian Kalocsay; Vaishali Sanchorawala; Shayna Sarosiek; Kristopher A. Sarosiek

doi:10.1038/s41467-022-33461-z

Nature Communications (Oct 2022)

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics

Cameron S. Fraser,
Johan K. E. Spetz,
Xingping Qin,
Adam Presser,
Jonathan Choiniere,
Chendi Li,
Stacey Yu,
Frances Blevins,
Aaron N. Hata,
Jeffrey W. Miller,
Gary A. Bradshaw,
Marian Kalocsay,
Vaishali Sanchorawala,
Shayna Sarosiek,
Kristopher A. Sarosiek

Affiliations

Cameron S. Fraser: John B. Little Center for Radiation Sciences, Harvard TH Chan School of Public Health
Johan K. E. Spetz: John B. Little Center for Radiation Sciences, Harvard TH Chan School of Public Health
Xingping Qin: John B. Little Center for Radiation Sciences, Harvard TH Chan School of Public Health
Adam Presser: John B. Little Center for Radiation Sciences, Harvard TH Chan School of Public Health
Jonathan Choiniere: John B. Little Center for Radiation Sciences, Harvard TH Chan School of Public Health
Chendi Li: Massachusetts General Hospital Cancer Center
Stacey Yu: John B. Little Center for Radiation Sciences, Harvard TH Chan School of Public Health
Frances Blevins: Section of Hematology & Medical Oncology, Boston Medical Center
Aaron N. Hata: Massachusetts General Hospital Cancer Center
Jeffrey W. Miller: Department of Biostatistics, Harvard TH Chan School of Public Health
Gary A. Bradshaw: Laboratory of Systems Pharmacology, Harvard Medical School
Marian Kalocsay: Laboratory of Systems Pharmacology, Harvard Medical School
Vaishali Sanchorawala: Section of Hematology & Medical Oncology, Boston Medical Center
Shayna Sarosiek: Section of Hematology & Medical Oncology, Boston Medical Center
Kristopher A. Sarosiek: John B. Little Center for Radiation Sciences, Harvard TH Chan School of Public Health

DOI: https://doi.org/10.1038/s41467-022-33461-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

Read online

Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al. show that BH3 mimetics, which inhibit pro-survival proteins BCL-2 or MCL-1, can effectively eliminate diseased cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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