Nature Communications (Aug 2022)
The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling
- Huanhuan Cui,
- Hongyang Yi,
- Hongyu Bao,
- Ying Tan,
- Chi Tian,
- Xinyao Shi,
- Diwen Gan,
- Bin Zhang,
- Weizheng Liang,
- Rui Chen,
- Qionghua Zhu,
- Liang Fang,
- Xin Gao,
- Hongda Huang,
- Ruijun Tian,
- Silke R. Sperling,
- Yuhui Hu,
- Wei Chen
Affiliations
- Huanhuan Cui
- Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology
- Hongyang Yi
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Hongyu Bao
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Ying Tan
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Chi Tian
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Xinyao Shi
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Diwen Gan
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Bin Zhang
- Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)
- Weizheng Liang
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Rui Chen
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Qionghua Zhu
- Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology
- Liang Fang
- Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology
- Xin Gao
- Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)
- Hongda Huang
- Department of Biology, School of Life Sciences, Southern University of Science and Technology
- Ruijun Tian
- Department of Chemistry, School of Science, Southern University of Science and Technology
- Silke R. Sperling
- Cardiovascular Genetics, Charité-Universitätsmedizin Berlin
- Yuhui Hu
- Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology
- Wei Chen
- Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-022-32472-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The functional role of DPF3, a component of the SWI/SNF chromatin remodelling complex associated with clear cell renal cell carcinoma (ccRCC), remains unknown. Here, the authors characterise the mechanism by which DPF3 promotes metastasis via the activation of the TGF-β signalling pathway in ccRCC.
